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Follow the progress of Hemolens Diagnostics
March 8, 2024
As we approach International Women’s Day, it’s essential to shed light on the unique aspects of women’s health, including heart health. Recent studies have highlighted distinct differences in coronary artery plaque burden between men and women, revealing valuable insights into cardiovascular disease.
In a study examining coronary artery plaque burden and distribution, researchers conducted a detailed analysis using coronary CT angiography (CCTA) and invasive fractional flow reserve (FFR). This analysis, part of the PACIFIC trial, involved 203 patients, with 63.5% being male, and included 581 vessels.
The findings were striking.
Men showed a higher frequency of ischemia compared to women, indicating a greater risk of impaired blood flow to the heart muscle.
Women, on the other hand, exhibited a smaller burden of all plaque subtypes, including calcified, non-calcified, and low-density non-calcified plaque.
Interestingly, while there was no significant difference in total, calcified, or non-calcified plaque burdens between men and women in vessels with ischemia, women had significantly lower levels of low-density non-calcified plaque burden. This suggests potential variations in plaque composition between the sexes.
Moreover, the study revealed that plaque burdens, regardless of subtype, were independently associated with ischemia in both men and women. Quantitative assessment of plaque burdens provided valuable predictive value for ischemia, supplementing traditional measures such as stenosis severity and adverse plaque characteristics.
These findings underscore the importance of personalized approaches to heart health, considering the differing risk profiles between men and women. By understanding these sex-specific differences in coronary artery plaque burden, healthcare professionals can better tailor preventive strategies and interventions for improved cardiovascular outcomes.
In conclusion, as we commemorate International Women’s Day, let’s not forget the significance of women’s heart health. Recognizing and addressing sex-related disparities in coronary artery disease is crucial for promoting overall well-being and longevity for everyone, regardless of gender.
Reference: J Cardiovasc Comput Tomogr. 2023 Mar-Apr;17(2):112-119.
https://doi.org/10.1016/j.jcct.2022.12.002
Intended Use:
Cardiolens FFR-CT Pro is a coronary physiologic simulation software for the clinical quantitative and qualitative analysis of previously acquired Coronary Computed Tomography Angiography (CCTA) and optionally with Continuous Non-invasive Blood Pressure (CNBP) data for assessment of patients with suspected Chronic Coronary Syndromes (CCS). It provides hemodynamic diagnostic factor FFR-CT (Fractional Flow Reserve with Computed Tomography), a mathematically derived quantity, computed from simulated pressure, velocity and blood flow information obtained from a 3D computer model generated from static coronary CT images and optionally from CNBP measurement. The factor FFR-CT at the output of Cardiolens FFR-CT Pro device is intended to support the functional evaluation of coronary artery disease. The Cardiolens FFR-CT Pro outputs are provided to support qualified clinicians to aid in the evaluation and assessment of coronary arteries. The results of Cardiolens FFR-CT Pro are intended to be used by qualified clinicians in conjunction with the patient’s clinical history, symptoms, and other diagnostic tests, as well as the clinician’s professional judgment.